李方方

时间:2020-07-04 07:57:40 来源:植物医学学院

一、基本情况

李方方,女,博士,研究员,硕士生/博士生导师。

 

二、 学习工作经历

工作经历:

2014.07–2015.05  浙江大学,农业与生物技术学院,助理研究员

2015.05–2018.08,加拿大农业与农业食品部,博士后

2015.05–2018.08,加拿大农业与农业食品部,助理研究员

2018.08–至今,   中国农业科学院植物保护研究所,研究员

学习经历:

2005.09 – 2009.06  南京农业大学,植物保护专业,获农学学士学位

2009.09 – 2014.06  浙江大学,植物病理学专业,获农学博士学位

  • 教学工作

植物病毒学

植物病理学

四、 研究方向及简介

主要从事植物与病毒的互作研究,以烟草、拟南芥和番茄为植物实验材料,以世界上危害最为严重、种类最多的两类植物病毒:双生病毒科病毒和马铃薯Y科病毒为研究对象,开展寄主植物与病毒的互作(双生病毒科病毒与寄主烟草和番茄的互作研究;芜菁花叶病毒与寄主拟南芥和烟草的互作研究)方面的研究工作。涉及的寄主途径包含DNA甲基化,RNA沉默,RNA降解,细胞自噬,泛素-26S蛋白酶体降解系统等。围绕着植物与病毒互作的机制,解析植物病毒致病的机制,进一步挖掘出新型有效的抗病基因。近几年部分研究结果以第一作者/共同第一作者或通讯作者身份在Nature Communications (1篇)、Trends in Microbiology(1篇)、Molecular Plant(1篇)、PLoS Pathogens(3篇)、New Phytologist(2篇)、Plant Physiology(1篇)、The Plant Journal(1篇)等专业杂志发表SCI收录论文16篇,累计影响因子106.4,引用次数超过300次;以参与作者身份在Trends in Plant Science、The Plant Cell、Frontiers in Plant Science等专业杂志上发表SCI收录论文8篇。

  • 科研课题
  1. 国家海外高层次人才项目,2019年4月至2022年4月,300.00万元;
  2. 国家自然科学基金面上项目(31972244),芜菁花叶病毒复制酶NIb核输出的功能与机理研究,2020年1月至2023年12月,60.00万元。

六、主要成果

l 论文

代表性论文(#共同第一作者,*共同通讯作者)

  1. Fangfang Li and Aiming Wang*. RNA-Targeted Antiviral Immunity: More Than Just RNA Silencing. Trends in Microbiology. 2019. IF: 11.776. Cited by: 3
  2. Fangfang Li *, Mingzhen Zhang, Changwei Zhang and Xueping Zhou. Nuclear autophagy degrades a geminivirus nuclear protein to restrict viral infection in Solanaceous plants. New Phytologist. 2019. IF: 7.299. Cited by: 1 
  3. Fangfang Li, Wende Liu and Xueping Zhou*. Pivoting plant immunity from theory to the field. Science China-Life Sciences. 2019. IF: 3.583. Cited by: 1
  4. Fangfang Li #, Xiongbiao Xu#, Zhenghe Li, Yaqin Wang* and Xueping Zhou. Identification of Yeast Factors Involved in the Replication of Mungbean Yellow Mosaic India Virus Using Yeast Temperature-Sensitive Mutants. Virological sinca. 2019, 1-4. IF: 2.467. Cited by: 0
  5. Fangfang Li, Changwei Zhang, Yinzi Li, Guanwei Wu, Xilin Hou, Xueping Zhou and Aiming Wang* Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase. Nature Communications. 2018, 9(1): 1268. IF: 12.124. Cited by: 29
  6. Fangfang Li, Xiuling Yang, David M Bisaro and Xueping Zhou*. The βC1 Protein of Geminivirus–Betasatellite Complexes: A Target and Repressor of Host Defenses. Molecular Plant. 2018, 11: 1424-1426. IF: 9.326. Cited by: 8
  7. Fangfang Li and Aiming Wang*. RNA decay is an antiviral defense in plants that is counteracted by viral RNA silencing suppressors. PLoS Pathogens. 2018, 148: e1007228. IF: 6.158. Cited by: 13
  8. Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang and Xueping Zhou*. A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana. PLoS Pathogens. 2017, 13(2): e1006213. IF: 6.608. Cited by: 59
  9. Fangfang Li, Changjun Huang, Zhenghe Li* and Xueping Zhou*. Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression. PLoS Pathogens. 2014, 10: e1003921.IF: 8.057. Cited by: 131
  10. Fangfang Li#, Xiongbiao Xu#, Changjun Huang, Zhouhang Gu, Linge Cao, Tao Hu, Ming Ding, Zhenghe Li* and Xueping Zhou*. The AC5 protein encoded by Mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing‐based antiviral defenses. New Phytologist. 2015, 208(2): 555-569. IF: 7.672. Cited by: 33
  11. Fangfang Li#, Weidi Wang#, Nan Zhao, Bingguang Xiao, Peijian Cao, Xingfu Wu, Chuyu Ye, Enhui Shen , Jie Qiu, Qian-Hao Zhu, Jiahua Xie, Xueping Zhou* and Longjiang Fan*. Regulation of Nicotine Biosynthesis by an Endogenous Target Mimicry of MicroRNA in Tobacco. Plant Physiology. 2015, 169(2): 1062-1071. IF: 6.841. Cited by: 53
  12. Sang‐Ho Park#, Fangfang Li#, Justin Renaud, Wentao Shen, Yinzi Li, Lihua Guo, Hongguang Cui, Mark Sumarah and Aiming Wang*. NbEXPA1, an α‐Expansin, Is Plasmodesmata‐Specific and a Novel Host Factor for Potyviral Infection. The Plant Journal. 2017. 92(5): 846-861. IF: 5.901. Cited by: 14
  13. Fangfang Li , Xiongbiao Xu, Xiuling Yang, Zhenghe Li and Xueping Zhou*. Identification of a cis-Acting Element Derived from Tomato Leaf Curl Yunnan Virus that Mediates the Replication of a Deficient Yeast Plasmid in Saccharomyces cerevisiae. Viruses. 2018, 10(10): 536. IF: 3.761. Cited by: 1
  14. Fangfang Li, Yaqin Wang and Xueping Zhou*. SGS3 Cooperates with RDR6 in Triggering Geminivirus-Induced Gene Silencing and in Suppressing Geminivirus Infection in Nicotiana benthamiana. Viruses. 2017, 9 (9): 247. IF: 3.465. Cited by: 5
  15. Xiaofei Cheng#, Fangfang Li#, Jianyu Cai, Wei Chen, Nan Zhao, Yuqiang Sun, Yushuang Guo, Xiuling Yang and Xiaoyun Wu*. Artificial TALE as a Convenient Protein Platform for Engineering Broad-Spectrum Resistance to Begomoviruses. Viruses. 2015, 7(8): 4772-4782. IF: 3.353. Cited by: 22
  16. Bi Wang#, Fangfang Li#, Changjun Huang, Xiuling Yang, YajuanQian, Yan Xie and Xueping Zhou*. V2 of Tomato yellow leaf curl virus can suppress methylation-mediated transcriptional gene silencing in plant. Journal of General Virology. 2014, 95: 225-230. IF: 3.529. Cited by: 66

l 专利

l 荣誉

  • 社会兼职

美国病毒学会(ASV)会员

PLoS Pathogens、Molecular Plant-Microbe Interactions、Frontiers in Plant Science、Scientific Reports等杂志审稿人

八、联系方式

通讯地址:山东省青岛市城阳区长城路700号,青岛农业大学植物医学学院

邮政编码:266109

联系电话:13641100481或010-62816620

E-mail: ffli@ippcaas.cn 或 elva1988@163.com

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